Tilarin (1% nedocromil sodium)
1. How useful is nedocromil sodium (Tilarin) to people who suffer from year-round allergic rhinitis?
Nedocromil sodium nasal spray has proven efficacy against seasonal bouts of allergic rhinitis and is most effective when dosed regularly throughout the pollen seasons. People who are allergic to several pollens (birch, grass, ragweed, etc.) may suffer more than one bout of seasonal allergic rhinitis during the year and on each occasion nedocromil sodium nasal spray can be used with confidence throughout the period of exposure to pollen allergens. There is no evidence of any loss of activity with continued use, or of any accumulation of the drug in the body tissues. Information regarding the use of the nasal spray in non-seasonal (house dust) allergic rhinitis is limited at the present time.
2. Which symptoms are most and least affected by nedocromil sodium (Tilarin)?
In general, itching and running of the nose and sneezing are most rapidly improved by nedocromil sodium nasal spray; stuffy nose may be less readily affected in some patients.
3. Is nedocromil sodium more effective in milder cases of rhinitis, or can it help even the worst sufferers?
Our clinical trials were carried out in patients with mild or moderate allergic rhinitis, and nasal corticosteroids are recommended to control more severe symptoms. However, nedocromil sodium nasal spray used in combination with antihistamine tablets can be a very effective additive therapy for allergic rhinitis.
4. Is this primarily an asthma drug that’s also useful for allergic rhinitis, or is it a rhinitis drug that’s also useful for asthma?
Nedocromil sodium reduces the allergic inflammatory reaction which occurs after sensitive tissues are exposed to allergens such as pollen, but it is also effective against inflammatory reactions to non-specific stimuli such as chemical air pollutants. Because of its anti-inflammatory properties when applied to the surface of the affected tissue, whether in the lung, the nose or the eye, nedocromil sodium is useful in asthma, allergic rhinitis and allergic conjunctivitis.
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